Neuroprotective Properties of Cannabidiol

E. Council, B.S. Research Biologist

Beyond anticonvulsant, antidepressant, and anxiolytic effects, cannabidiol shows additional neuroprotective properties in models of neurological disorders. Studies show CBD effectively improves cognitive decline associated with neurological disorders, promotes neurogenesis, decreases blood-brain barrier permeability, and helps maintain a normal heartbeat to supply the brain with oxygen-rich blood. These characteristics provide protection from brain damage associated with neurodegenerative diseases and ischemic conditions such as stroke.

Neuroinflammation and oxidative stress are driving factors of brain damage associated with neurodegenerative diseases and brain ischemia. Research suggests that CBD acts through peroxisome proliferator-activated receptor gamma to suppress the activity of proinflammatory mediators, resulting in a reduced neuroinflammation. The antioxidant properties of CBD suppress oxidative stress by scavenging reactive nitrogen/oxygen species and preventing lipid peroxidation. Furthermore, CBD can prevent neurodegeneration by stimulating neurogenesis and improve cognitive decline by normalizing Ca2+ levels and enhancing acetylcholine levels, brain-derived neurotrophic factor levels, and anandamide levels. CBD protects the brain from damage in ischemic conditions by modulating a normal heartbeat and normal BBB permeability. Together, these data show neuroprotective properties of CBD beyond anticonvulsant, antidepressant, and anxiolytic effects.

This information was gathered from “Neuroprotective Properties of Cannabidiol: A Narrative Review”. For more information see:

Council, E. (2019) Neuroprotective Properties of Cannabidiol: A Narrative Review. Manuscript Submitted for Publication.