Cannabidiol Reduces Inflammation

E. Council, B.S. Research Biologist

Inflammation is a protective immune response to stimulation by pathogens or endogenous signals such as damaged cells. Because first-line inflammation is crucially important for keeping the body healthy, it is an intricate immune response with many other influential factors. With such a plethora of influential factors, it is difficult for the body to maintain immune homeostasis. If this first-line inflammatory response becomes persistent, due to loss of immune homeostasis, inflammation may become chronic and contribute to age-related conditions, atherosclerosis, neurodegenerative diseases and cancer, among others.

Cannabidiol works by enhancing the body’s endocannabinoid system, a biological system that functions to maintain immune and nervous homeostasis. In addition, cannabidiol can interact with inflammatory-control receptors outside of the endocannabinoid system to relay anti-inflammatory effects. Research shows cannabidiol significantly reduces major proinflammatory factors like the release of proinflammatory cytokines, vasodilation, and leukocyte rolling. Cannabidiol has effectively reduced inflammation in models of arthritis, neurodegenerative diseases, irritable bowel syndrome, amongst others. Moreover, cannabidiol relieves inflammation without adverse side effects or formation of dependency.

This information was gathered from “Cannabidiol Reduces Inflammation: A Narrative Review”. For more information see:

Council, E. (2019) Cannabidiol Reduces Inflammation: A Narrative Review. Manuscript Submitted for Publication.